Bills 36, Ravens 10: Lamar Jackson Hurt on First Play, Headed for Thumb Surgery and Injured Reserve

ORCHARD PARK, NEW YORK — Lamar Jackson hurt his thumb on the Ravens' first offensive play Sunday, and Baltimore lost 36-10 to the Buffalo Bills at Highmark Stadium, its third straight loss. Head coach Jesse Minter said after the game that Jackson will have surgery and go on injured reserve, and asked whether that could be season-ending, said, "potentially." The team's website reports Jackson will miss at least the next four games.

Jackson's hand hit Bills pass rusher Greg Rousseau as he threw. Backup Tyler Huntley left in the second quarter with a toe injury, and undrafted rookie Joe Fagnano went 10 of 21 for 91 yards with an interception and a lost fumble in his NFL debut. The Bills had four sacks and 12 quarterback hits and outgained Baltimore 426 yards to 144. "It's tough," Minter said. "When it happened, I think at the time, you're just hoping that maybe it's something small, and then I think pretty quickly kind of realized what had happened."

Derrick Henry's 2-yard touchdown run, set up by Broderick Washington Jr.'s first career interception, brought his career rushing-touchdown total to 130. The Ravens, now 4-4, host the Jacksonville Jaguars (5-2) on Thursday night, four days after the loss.